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MYP_026899
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Basic Information
Dermaseptin-S4
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ CPE inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C132H229N35O32S
Standard
Sequence
ALWMTLLKKVLKAAAKAALNAVLVGANA
Physicochemical Analysis
2850.51 Da
10.48
3.79
3.60
0.1354
1.03
0.71
0.34
10.37
146.79
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1075.30
-6.33
37.0
37.0
96.0
200.0
2.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0073537 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Spermicidal
T. metagrophytes IP877-71
20 μM
MIC
PaperThe Vertebrate Peptide Antibiotics Dermaseptins Have Overlapping Structural Features but Target Specific Microorganisms
RECORD: Rec_0075099 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum W2
1 μM
Percent inhibition; [3H] Hypoxanthine incorporation assay
PaperAntimalarial activities of dermaseptin S4 derivatives PMID10952593 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10952593/
RECORD: Rec_0077355 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorophore labeling
Amidation
N-term detail: Labelled rhodamine
Bio-Activity Profile
Cell-penetrating peptide Antimicrobial
HeLa
Fluorescence-based uptake assay
PMID12119035 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12119035/
RECORD: Rec_0080322 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Labelled rhodamine
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0096414 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
E. coli Urine DS, S2 = E. coli Urine MDR, S3 = K. pneumoniae Urine DS, S4 = C. striatum Wound exudate MDR, S5 = C. striatum Wound exudate MDR, S6 = C. striatum Wound exudate MDR, S7 = C. striatum Wound exudate MDR (DS = drug sensitive, MDR = multi drug resistant)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S7
411.06 μg/mL
MIC
PMID33774792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33774792/
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