MYP_026899
Dermaseptin-S4
Anticancer
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Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antimicrobial
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Antibacterial
Antimicrobial
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Antibacterial
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Anti-Gram-negative
Antimicrobial
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Antibacterial
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Anti-Gram-positive
Antimicrobial
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Antifungal
Antiparasitic
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Antimalarial
Antiparasitic
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Antiprotozoal
Antiparasitic
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Antiprotozoal
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Antimalarial
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Anti-Plasmodium
Antiparasitic
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General antiparasitic
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Antiparasitic
Antiviral
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Anti-Herpesvirus
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Antiviral
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Anti-HIV
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Delivery / Targeting
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Cell penetration
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Cell-penetrating peptide
Delivery / Targeting
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Drug delivery vehicle
Enzyme modulation
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Enzyme inhibition
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CPE inhibition
Enzyme modulation
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Enzyme inhibition
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Infection inhibition
Reproductive biology
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Contraceptive activity
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Spermicidal
Toxicity / Safety
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Blood cell toxicity
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Hemolysis
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Hemolytic
Toxicity / Safety
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Cytolysis / cell lysis
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Cytolytic activity
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Venom / Toxin
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General toxin
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Cytotoxic
Venom / Toxin
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General toxin
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Toxic
Standard
28 amino acids
C132H229N35O32S
Standard
ALWMTLLKKVLKAAAKAALNAVLVGANA
2850.51 Da
10.48
3.79
3.60
0.1354
1.03
0.71
0.34
10.37
146.79
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1075.30
-6.33
37.0
37.0
96.0
200.0
2.0
29.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0366896
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Dermaseptin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Antifungal
and the enveloped herpes simplex virus type 1
RECORD: Rec_0370154
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Hemolytic
Cytolytic
Erythrocytes
1.5 μM
HC50
RECORD: Rec_0374918
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Antiparasitic
Antimalarial
Plasmodium falciparum HB3
<10 μM
Percent inhibition; [3H] Hypoxanthine incorporation assay
RECORD: Rec_0375948
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
E. coli Urine DS, S2 = E. coli Urine MDR, S3 = K. pneumoniae Urine DS, S4 = C. striatum Wound exudate MDR, S5 = C. striatum Wound exudate MDR, S6 = C. striatum Wound exudate MDR, S7 = C. striatum Wound exudate MDR (DS = drug sensitive, MDR = multi drug resistant)
Bio-Activity Profile
Hemolytic
RBC
8 μg/mL
Hemolysis
RECORD: Rec_0379409
VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Dermaseptin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Antifungal
fungi
Showing 5 records on this page · Page 12 of 14