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MYP_026897
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Basic Information
Spexin-1
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Standard
14 amino acids
C74H113N19O20S
Standard
Sequence
NWTPQAMLYLKGAQ
Physicochemical Analysis
1620.87 Da
8.59
0.76
0.55
0.0541
-0.44
0.26
0.12
-13.29
70.00
0.1429
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
644.37
-4.69
21.0
22.0
50.0
114.0
4.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0167612 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal] [Animal]; Rattus norvegicus [Animal] [Animal]; Bos taurus [Animal] [Animal]; Mus musculus [Animal]
9606;10116;9913;10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone
Inhibits adrenocortical cell proliferation
RECORD: Rec_0298366 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
-
PMID22038051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038051/
RECORD: Rec_0305738 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Spexin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Myotropic
Mammalian: 1.4 hour; Yeast: 3 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Spexin (Homo sapiens): PMID 22038051 PMID22038051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038051/
RECORD: Rec_0322734 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/