Peptide Database

Peptide NameRFamide ligand for orphan G-protein-coupled receptor SP9155, P517

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC52H76N14O11

DescriptionStandard

        KKGGFSFRF
    

Molecular Weight1073.25 Da

Isoelectric Point (pI)11.17

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.3065

GRAVY Index-0.61

Hydrophobic Moment 0.35

Boman Index-0.13

Instability Index13.17

Aliphatic Index 0.00

Aromaticity 0.3333

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 430.29

LogP -3.22

H-bond Donors 16.0

H-bond Acceptors 14.0

Rotatable Bonds 36.0

Heavy Atoms 77.0

Ring Count 3.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0243702 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

Targethuman SP9155 / GPR103 (QRFPR) receptor

Activity235±6 nM

MethodEC50; FLIPR Ca2+ mobilization assay in SP9155-transfected 293SFM cells