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MYP_026799
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Basic Information
sst3-ODN-8
Neurological / Signaling ▸ Receptor modulation ▸ Agonist
Neurological / Signaling ▸ Receptor modulation ▸ Antagonist
Neurological / Signaling ▸ Signaling peptide
not Standard
8 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
CFYXKTFC
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0309292 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GtoPdb peptide ligand
Structure & Mods
synthetic linear peptide [Linear]
noncanonical/mixed stereochemistry [Modified]
Disulfide bond between terminal cysteine residues (sequence positions 1-8)
N-terminal carbamoylation; d-Cys; Tyr substitution; d-Agl(Me,2-naphthoyl) noncanonical residue
Bio-Activity Profile
Receptor antagonist Signaling peptide
human SST3 receptor; SST3-transfected CCL39 cells
9.07 pKB
cAMP functional antagonism assay
PaperA novel selective somatostatin agonist with high affinity for the human somatostatin receptor subtype 3 PMID11095748 Evidence URLhttps://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2077
RECORD: Rec_0432962 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GtoPdb peptide ligand
Structure & Mods
synthetic linear peptide [Linear]
noncanonical/mixed stereochemistry [Modified]
Disulfide bond between terminal cysteine residues (sequence positions 1-8)
N-terminal carbamoylation; d-Cys; Tyr substitution; d-Agl(Me,2-naphthoyl) noncanonical residue
Bio-Activity Profile
Receptor antagonist Signaling peptide
human SST3 receptor; SST3-transfected CCL39 cells
9.22 pKi
phospholipase C functional antagonism assay
PaperA novel selective somatostatin agonist with high affinity for the human somatostatin receptor subtype 3 PMID11095748
RECORD: Rec_0432963 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GtoPdb peptide ligand
Structure & Mods
synthetic linear peptide [Linear]
noncanonical/mixed stereochemistry [Modified]
Disulfide bond between terminal cysteine residues (sequence positions 1-8)
N-terminal carbamoylation; d-Cys; Tyr substitution; d-Agl(Me,2-naphthoyl) noncanonical residue
Bio-Activity Profile
Receptor antagonist Signaling peptide
human SST3 receptor; SST3-transfected CCL39 cells
0.27 nM
radioligand binding assay (KD)
PaperA novel selective somatostatin agonist with high affinity for the human somatostatin receptor subtype 3 PMID11095748