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MYP_026794
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HPV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
33 amino acids
C177H280N54O48S3
Standard
Sequence
YKFACPECPKRFMRSDHLSKHITLHELLGEERR
Physicochemical Analysis
4028.64 Da
8.82
2.01
1.61
0.0609
-0.91
0.69
-0.28
112.44
62.12
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1656.06
-13.51
61.0
56.0
135.0
282.0
8.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0099939 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Host-derived peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human papillomavirus (E6 protein)
19.3 μM
CD spectroscopy
PaperDesign and characterization of helical peptides that inhibit the E6 protein of papillomavirus. | Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. | Biochemistry. 2004 | PMID:15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0127262 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0148283 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human papillomavirus(HPV):inhibition of E6-E6ap interaction
19.3±2.9 μM
IC50
PaperPubMed PMID: 15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0153362 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0160901 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HPV Entry inhibition
Human papillomavirus(HPV)
19.3±2.9 μM
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperDesign and characterization of helical peptides that inhibit the E6 protein of papillomavirus. | Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. | Biochemistry. 2004 Jun 15;43(23):7421-31. | DOI:10.1021/bi049552a | PMID:15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/