Peptide Database

Peptide NameHuman beta defensin 3

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC169H292N50O50S5

DescriptionStandard

        GIINMLQKSYCKIRKGRCALLGCLPKEEQIGSCSVSG
    

Molecular Weight3984.76 Da

Isoelectric Point (pI)9.17

Net Charge (pH 7.0)3.72

Net Charge (pH 7.4) 3.45

Charge Density (pH 7.0) 0.1006

GRAVY Index0.02

Hydrophobic Moment 0.55

Boman Index0.01

Instability Index44.89

Aliphatic Index 94.86

Aromaticity 0.0270

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1635.03

LogP -17.87

H-bond Donors 61.0

H-bond Acceptors 59.0

Rotatable Bonds 140.0

Heavy Atoms 274.0

Ring Count 2.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0246602 VERIFIED: YES

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)