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MYP_026605
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Basic Information
Gaegurin-4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
37 amino acids
C165H287N45O49S2
Standard
Sequence
GILDTLKQFAKGVGKDLVKGAAQGVLSTVSCKLAKTC
Physicochemical Analysis
3749.45 Da
9.51
3.74
3.49
0.1010
0.33
0.67
0.13
4.90
105.41
0.0270
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1528.97
-16.53
55.0
55.0
132.0
261.0
1.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0176975 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Serratia marcescens
200 μg/mL
MIC
PaperAntimicrobial peptides from the skin of a Korean frog, Rana rugosa. Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. doi: 10.1006/bbrc.1994.2757. PMID: 7999137. PMID7999137;17141187;11004488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0189138 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Saccharomyces cerevisiae
200 μg/mL
MIC
PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0199678 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Shigella dysentariae
25 μg/mL
MIC
PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0221887 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10785392/ PMID10785392 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10785392/
RECORD: Rec_0225821 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Candida albicans
200 μg/mL
MIC
PaperAntimicrobial peptides from the skin of a Korean frog, Rana rugosa. Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. doi: 10.1006/bbrc.1994.2757. PMID: 7999137. PMID7999137;17141187;11004488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
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