Peptide Database

Peptide NameSLAY-screened peptide P5667

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC76H118N18O24S2

DescriptionStandard

        SDYTPMRTYVCSVIP
    

Molecular Weight1731.99 Da

Isoelectric Point (pI)5.55

Net Charge (pH 7.0)-0.55

Net Charge (pH 7.4) -0.78

Charge Density (pH 7.0) -0.0367

GRAVY Index0.03

Hydrophobic Moment 0.33

Boman Index0.09

Instability Index-8.30

Aliphatic Index 64.67

Aromaticity 0.1333

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 673.72

LogP -6.38

H-bond Donors 25.0

H-bond Acceptors 26.0

Rotatable Bonds 49.0

Heavy Atoms 120.0

Ring Count 4.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0151565 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/