Peptide Database

Peptide NameProbable insulin-like peptide beta-type 5

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length54 amino acids

Chemical FormulaC230H379N69O79S9

DescriptionStandard

        VPAPGETRACGRKLISLVMAVCGDLCNPQEGKDIATECCGNQCSDDYIRSACCP
    

Molecular Weight5663.47 Da

Isoelectric Point (pI)4.66

Net Charge (pH 7.0)-2.34

Net Charge (pH 7.4) -2.68

Charge Density (pH 7.0) -0.0432

GRAVY Index-0.09

Hydrophobic Moment 0.57

Boman Index-0.01

Instability Index60.18

Aliphatic Index 68.70

Aromaticity 0.0185

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2363.04

LogP -30.68

H-bond Donors 87.0

H-bond Acceptors 86.0

Rotatable Bonds 183.0

Heavy Atoms 387.0

Ring Count 5.0

Amide Bonds 57.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0040833 VERIFIED: YES

Provenance & Taxonomy

OrganismCaenorhabditis elegans [Animal]

FamilyProbable insulin-like peptide beta-type

Tax ID6239

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide10-39; 22-52; 26-53; 38-43

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation Immunomodulatory

Half-LifeMammalian: 100 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0058623 VERIFIED: YES

Provenance & Taxonomy

OrganismCaenorhabditis elegans [Animal]

FamilyProbable insulin-like peptide beta-type

Tax ID6239

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide10-39; 22-52; 26-53; 38-43

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation Immunomodulatory

TargetAWC sensory neurons to regulate high salt chemotaxis responses (PubMed:24013594)

Half-LifeMammalian: 100 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0333318 VERIFIED: YES

Provenance & Taxonomy

OrganismCaenorhabditis elegans [Animal]

Familyinsulin family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide10-39; 22-52; 26-53; 38-43

Bio-Activity Profile

Function

Hormone Insulin family