‹ ›
MYP_026517
← PREVIOUS NEXT → BACK
Basic Information
SynB3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
10 amino acids
C60H101N25O14
Standard
Sequence
RRLSYSRRRF
Physicochemical Analysis
1396.60 Da
12.00
4.76
4.55
0.4759
-1.88
0.60
-1.05
200.10
39.00
0.2000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
695.41
-7.70
29.0
19.0
47.0
99.0
2.0
9.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0271055 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Conjugation with NBD
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery Antimicrobial
PMID12783857 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12783857/
RECORD: Rec_0304697 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: 2-pyrrolinodoxorubicin
Bio-Activity Profile
Anticancer
Paper2-Pyrrolinodoxorubicin and its peptide-vectorized form bypass multidrug resistance Evidence URLhttps://doi.org/10.1097/01.cad.0000132231.28888.fa
RECORD: Rec_0356938 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
NBD and TAMRA
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID12783857 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12783857/
RECORD: Rec_0363916 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
NBD
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID12783857 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12783857/
RECORD: Rec_0366491 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
SynB/Protegrin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorophore labeling
None
N-term detail: Labelled with NBD and TAMRA
Bio-Activity Profile
Cell-penetrating peptide Antimicrobial
K562 cells
Fluorescence-based uptake assay
PMID12783857 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12783857/
FIRST PREV 1 2 3
Showing 5 records on this page · Page 3 of 3