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MYP_026514
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Basic Information
GST-removed HR2(1145-1192)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
48 amino acids
C235H384N62O82
Standard
Sequence
DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYI
Physicochemical Analysis
5389.93 Da
4.11
-6.23
-6.45
-0.1297
-0.32
0.70
-0.00
30.41
125.83
0.0417
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2389.85
-23.31
78.0
76.0
190.0
379.0
2.0
55.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0031445 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 18442051 PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/
RECORD: Rec_0046644 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV‐luc/SARS Pseudotyped Virus:inhibition of viral-entry in Vero E3 cells
2.15 μM
EC50
PaperPubMed PMID: 18442051 PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/
RECORD: Rec_0086879 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV PsV
PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/
RECORD: Rec_0165970 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV‐luc/SARS Pseudotyped Virus | E3 cells
2.15 μM
EC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperFusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors. | Chu LH, Chan SH, Tsai SN, Wang Y, Cheng CH, Wong KB, Waye MM, Ngai SM. | J Cell Biochem. 2008 Aug 15;104(6):2335-47. | DOI:10.1002/jcb.21790 | PMID:18442051 PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/
RECORD: Rec_0202622 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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