Peptide Database

Peptide NameSLAY-screened peptide P456

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H154N34O31S

DescriptionStandard

        TNGHDRKKDTFSCPFISNRH
    

Molecular Weight2360.57 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)1.56

Net Charge (pH 7.4) 1.25

Charge Density (pH 7.0) 0.0781

GRAVY Index-1.48

Hydrophobic Moment 0.30

Boman Index-0.40

Instability Index34.55

Aliphatic Index 19.50

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1082.33

LogP -14.63

H-bond Donors 39.0

H-bond Acceptors 36.0

Rotatable Bonds 77.0

Heavy Atoms 166.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0128339 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/