Peptide Database

Peptide NameCyclic cationic V1 peptide

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC89H167N25O21S2

DescriptionStandard

        CVKVKVKVGSGVKVKVKVC
    

Molecular Weight1987.56 Da

Isoelectric Point (pI)10.05

Net Charge (pH 7.0)5.73

Net Charge (pH 7.4) 5.49

Charge Density (pH 7.0) 0.3018

GRAVY Index0.72

Hydrophobic Moment 0.36

Boman Index0.05

Instability Index-34.87

Aliphatic Index 122.11

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 763.47

LogP -5.74

H-bond Donors 29.0

H-bond Acceptors 29.0

Rotatable Bonds 72.0

Heavy Atoms 137.0

Ring Count 0.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0405166 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetTHP-1

Activity45 μM

MethodIC50

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