Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length535 amino acids

Chemical FormulaC2748H4305N697O769S19

DescriptionStandard

        MPTGPNFCIRSEYKMCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGVEMIEQMVKERKIPDLKGSESPKFLKIDYMNYKLINIKINAFSLPNTSLAFVPGVGIRALIKHGTANISTDWEIKSPLFQDTGGANLLLSGVYFTGILVLARNDFGHPILKLQDCNAQVSRNDISFSGELSVLYNSFAEPMEKPILKNLNKMLCPIITSEVEALNANLSMLEVLRSVDNYTLLDYSLISSPEITENYIDLNLKGVFYPLENLTDPPFSSVPFVLPEHNDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTKKIFNHLIRNSQGLGNMLSWIAELYILSQPFMVQVLAREPPVVNLLPGHFTLDIPASFVILTQSKNSTAETVLSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESIRSNIEVFRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSLKQQSSFHGWEALNLIRGRWRGKPAPWLPVWSPLQEVNRP
    

Molecular Weight60020.02 Da

Isoelectric Point (pI)8.07

Net Charge (pH 7.0)2.19

Net Charge (pH 7.4) 1.36

Charge Density (pH 7.0) 0.0041

GRAVY Index0.11

Hydrophobic Moment 0.71

Boman Index0.15

Instability Index46.56

Aliphatic Index 105.51

Aromaticity 0.1028

Extinction Coeff. Reduced 70820.00

Extinction Coeff. Oxidized 71195.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0037609 VERIFIED: NO

Provenance & Taxonomy

OrganismTursiops truncatus [Animal]

FamilyBPI

Tax ID9739

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence