Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length431 amino acids

Chemical FormulaC2143H3382N544O629S18

DescriptionStandard

        MNIAYGLTFLFSMAAFVGATDTGNPGFVVRLTQKGLDYALQEGMIVLQQQLFQIQLPDFSGTYDVGVLGKVKYRFSSMTISSVQLPSYQVIPVPDKGLKLSISGAFIQVDGRWDVRYSFIHEDGSFNIKVLGISISVGLILGSDESGRPTIAPSDCSCHISNVEVHMSGTIGWLVDLFHNNVESELRQSMENKICPEVTQSISSKLLSLLQTLPVTTKIDQISAIDYSLTGPPSVMANWIDVLLKGEFFDISHRTTPPFSPPVMSLPPEQDLMVYFAVSEYLFNTAGFVYQDAGALVFNLTDDMIPKESSMHLNTSSFGILIPSISKMYPNMLMKLKISTASAPALNIKPGNLTLSPVGNIQAYAILPNSSLAPLFLLQLNTNVLAKVAVNSGKIVGSLELDKSLREPWSYNLIQRYLKMQNQSIQNRRKD
    

Molecular Weight47408.21 Da

Isoelectric Point (pI)5.90

Net Charge (pH 7.0)-3.97

Net Charge (pH 7.4) -4.63

Charge Density (pH 7.0) -0.0092

GRAVY Index0.12

Hydrophobic Moment 0.65

Boman Index0.16

Instability Index46.41

Aliphatic Index 101.51

Aromaticity 0.0882

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 42985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0311734 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyBPI/LBP

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria