Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length471 amino acids

Chemical FormulaC2349H3684N600O690S18

DescriptionStandard

        MAAEGFPCNILSLVVCYSKGLVFTLQRRAREVGLEILKQNMEKEHFPDLTGHEKFGLGNVKYNISRIHVTAVELPSASISLLPGSGIKLVIGNASLTIDMNWNIRTWMFKDSGRGTVHISKVFVTAILSTPLDNAGPTSIALTSCRTTPGDVNIKLNGKTGFLYNFFIKYLKKPIHRSLVTNSCPNIRAGIQLIDGDLRSPNAVMQIDDLAEVDYSLSGLPAVFQTFIDLDLKGVVFPAGNHTDSPYMAASFTIPDQSDSMLYLAFSEYFFQSSSFAYYTAGAFNMTIAEETCSYFNINTEIFSSIIPEVAKYSITPYPVMLKLMSTEIPTISLQQDSFTAEIQGSVEVLAILPDSTTQSLFTLNIAANTSISLNIFDQKLMGSLCLNRIQFSLAHSNVGSFEVVLLENILSYIFQTEVIPSANAKLSKGFPLPNLANVTLTRPHIAIVQGYVLISTDAHYKHYRRRETTC
    

Molecular Weight51947.15 Da

Isoelectric Point (pI)6.21

Net Charge (pH 7.0)-3.66

Net Charge (pH 7.4) -4.58

Charge Density (pH 7.0) -0.0078

GRAVY Index0.15

Hydrophobic Moment 0.77

Boman Index0.16

Instability Index46.63

Aliphatic Index 99.17

Aromaticity 0.0977

Extinction Coeff. Reduced 36330.00

Extinction Coeff. Oxidized 36705.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0147294 VERIFIED: NO

Provenance & Taxonomy

OrganismJunco hyemalis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence