Peptide Database

Peptide NameIPB05(SARS-CoV-2-S (1179-1205))

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC135H232N38O46

DescriptionStandard

        IQKEIDRLNEVAKNLNESLIDLQELGK
    

Molecular Weight3123.51 Da

Isoelectric Point (pI)4.66

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.44

Charge Density (pH 7.0) -0.0826

GRAVY Index-0.64

Hydrophobic Moment 0.69

Boman Index-0.16

Instability Index37.17

Aliphatic Index 130.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1419.36

LogP -13.11

H-bond Donors 46.0

H-bond Acceptors 44.0

Rotatable Bonds 115.0

Heavy Atoms 219.0

Ring Count 0.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389438 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermChol

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetSARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC>25 μM)

RECORD: Rec_0408012 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV Fusion inhibition

TargetHIV-luc/SARS pseudotyped virus | 293T cells

Activity1.19 μM

MethodEC50

Half-LifeMammalian: 20 h; Yeast: 30 min; E. coli: >10 h

PaperSuppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. | Yuan K, Yi L, Chen J, Qu X, Qing T, Rao X, Jiang P, Hu J, Xiong Z, Nie Y, Shi X, Wang W, Ling C, Yin X, Fan K, Lai L, Ding M, Deng H. | Biochem Biophys Res Commun. 2004 Jul 2;319(3):746-52. | DOI:10.1016/j.bbrc.2004.05.046 | PMID:15184046 PMID15184046 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15184046/

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