Peptide Database

Peptide NameTroHepc2-22

Function Ontology

Antimicrobial

Standard StatusStandard

Sequence Length22 amino acids

Chemical FormulaC100H166N32O23S8

DescriptionStandard

        GIKCRFCCGCCIPRVCGLCCRF
    

Molecular Weight2441.11 Da

Isoelectric Point (pI)8.78

Net Charge (pH 7.0)3.68

Net Charge (pH 7.4) 3.36

Charge Density (pH 7.0) 0.1673

GRAVY Index1.02

Hydrophobic Moment 0.62

Boman Index0.09

Instability Index-2.91

Aliphatic Index 66.36

Aromaticity 0.0909

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 877.35

LogP -8.38

H-bond Donors 40.0

H-bond Acceptors 35.0

Rotatable Bonds 77.0

Heavy Atoms 163.0

Ring Count 3.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0421067 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsAPD analysis reveals that this sequence is similar (81.82%) to hepcidin TH1-5 C: 36%, G=R: 14%.Chemical modification: N-terminal acetylation and C-terminal amidation

Bio-Activity Profile

Function

Antimicrobial

TargetEscherichia coli ATCC8739

Activity128 μM

MethodMIC

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