Peptide Database

Peptide NameSLAY-screened peptide P3382

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC58H92N16O16S

DescriptionStandard

        TPTWAPCLSRIG
    

Molecular Weight1301.51 Da

Isoelectric Point (pI)7.91

Net Charge (pH 7.0)0.39

Net Charge (pH 7.4) 0.18

Charge Density (pH 7.0) 0.0324

GRAVY Index0.12

Hydrophobic Moment 0.48

Boman Index0.17

Instability Index25.98

Aliphatic Index 73.33

Aromaticity 0.0833

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 504.22

LogP -4.84

H-bond Donors 19.0

H-bond Acceptors 18.0

Rotatable Bonds 35.0

Heavy Atoms 91.0

Ring Count 4.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0166087 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/