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MYP_026184
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Basic Information
Melittin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Gene expression inhibitor
Insecticidal/Pest control ▸ Insecticidal activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
26 amino acids
C131H228N38O32
Standard
Sequence
GIGAVLKVLTTGLPALISWIKRKRQQ
Physicochemical Analysis
2847.45 Da
12.00
4.76
4.55
0.1830
0.27
0.57
0.10
44.73
135.00
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1146.55
-8.48
41.0
37.0
97.0
201.0
3.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0032227 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Fusion inhibition
Herpes simplex virus type 1 (HSV-1) | Vero cells
1.35 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. | Albiol Matanic VC, Castilla V. | Int J Antimicrob Agents. 2004 Apr;23(4):382-9. | DOI:10.1016/j.ijantimicag.2003.07.022 | PMID:15081088 PMID15081088 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15081088/
RECORD: Rec_0037292 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Melittin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID29859288;29783753;6309516;20472009;20403370;5300771 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29859288/
RECORD: Rec_0047352 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0052530 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Melittin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
80 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10795591/ PMID10795591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10795591/
RECORD: Rec_0059824 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Melittin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
200 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/12168695/ PMID12168695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12168695/
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