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MYP_026184
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Basic Information
Melittin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Gene expression inhibitor
Insecticidal/Pest control ▸ Insecticidal activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
26 amino acids
C131H228N38O32
Standard
Sequence
GIGAVLKVLTTGLPALISWIKRKRQQ
Physicochemical Analysis
2847.45 Da
12.00
4.76
4.55
0.1830
0.27
0.57
0.10
44.73
135.00
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1146.55
-8.48
41.0
37.0
97.0
201.0
3.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0322307 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Melittin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
BEL-7402
PaperGrowth arrest and apoptosis of the human hepatocellular carcinoma cell line BEL-7402 induced by melittin PMID16974113 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16974113/
RECORD: Rec_0329840 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 50.0%, E 0.0%, T 30.8%, C 19.2% [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Toxic Hemolytic Cytotoxic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0333493 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Melittin
7460
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa 27853
2 μM
MIC
PMID31199117 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31199117/
RECORD: Rec_0340930 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Melittin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Salmonella enterica subsp enterica CMCC 50071
2 μM
MIC
PMID29859288;29783753;6309516;20472009;20403370;5300771 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29859288/
RECORD: Rec_0346709 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hemolytic
Mouse erythrocytes
6 μM
Paperhttps://pubmed.ncbi.nlm.nih.gov/16848415/ PMID16848415 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16848415/
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