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MYP_026184
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Basic Information
Melittin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Gene expression inhibitor
Insecticidal/Pest control ▸ Insecticidal activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
26 amino acids
C131H228N38O32
Standard
Sequence
GIGAVLKVLTTGLPALISWIKRKRQQ
Physicochemical Analysis
2847.45 Da
12.00
4.76
4.55
0.1830
0.27
0.57
0.10
44.73
135.00
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1146.55
-8.48
41.0
37.0
97.0
201.0
3.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0306479 VERIFIED: NO
Provenance & Taxonomy
Apis mellifera [Animal]
melittin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Formylation
Amidation
Bio-Activity Profile
Toxin Venom melittin family
PaperPDB 1BH1 structural record; NMR; chain A; residues 1-26
RECORD: Rec_0307237 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Melittin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Cytolytic
Mouse erythrocytes
120 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/8027544/ PMID8027544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8027544/
RECORD: Rec_0311740 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Melittin
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
E42/02
1.8±0.1 μM
IC50
PMID23893605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23893605/
RECORD: Rec_0312121 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Melittin
7460
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer Antiparasitic Insecticidal
Bacillus subtilis
2-4 μg/mL
MIC
PaperAntibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. USNRDL-TR-67-101.
RECORD: Rec_0312329 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Melittin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania donovani R9
LD50; MTT assay
PaperThe plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide PMID9461543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9461543/
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