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MYP_026184
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Basic Information
Melittin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Gene expression inhibitor
Insecticidal/Pest control ▸ Insecticidal activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
26 amino acids
C131H228N38O32
Standard
Sequence
GIGAVLKVLTTGLPALISWIKRKRQQ
Physicochemical Analysis
2847.45 Da
12.00
4.76
4.55
0.1830
0.27
0.57
0.10
44.73
135.00
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1146.55
-8.48
41.0
37.0
97.0
201.0
3.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003206 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Fusion inhibition
Enterovirus A71 (EV-A71) | HeLa cells
0.2669±0.01054 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperMelittin: a venom-derived peptide with promising anti-viral properties. | Memariani H, Memariani M, Moravvej H, Shahidi-Dadras M. | Eur J Clin Microbiol Infect Dis. 2020 Jan;39(1):5-17. | DOI:10.1007/s10096-019-03674-0 | PMID:31422545 PMID31422545 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31422545/
RECORD: Rec_0005793 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Melittin
7460
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa PAO1
2 μM
MIC
PMID31199117 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31199117/
RECORD: Rec_0009488 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Melittin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
23 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/19635451/ PMID19635451 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19635451/
RECORD: Rec_0021326 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Melittin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania donovani (promastigote)
0.3 μM
IC50; Not_Available
PaperThe plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide PMID9461543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9461543/
RECORD: Rec_0025573 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]; Insecta [Animal]
Melittin
32630; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID23893605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23893605/
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