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MYP_026107
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Basic Information
PB1 (381-400)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
20 amino acids
C105H180N30O31
Standard
Sequence
FNESTRKKIEKIRPLLVEGT
Physicochemical Analysis
2358.74 Da
9.70
1.77
1.55
0.0883
-0.77
0.54
-0.25
37.99
92.50
0.0500
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1024.97
-9.03
36.0
33.0
83.0
166.0
2.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0066604 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Contains non-standard symbols/residues: .
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Influenza A virus(A/California/07/2009 (H1N1)pdm09/) | MDCK cells
23±1 μM
ED50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperSynthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments. | Matusevich OV, Egorov VV, Gluzdikov IA, Titov MI, Zarubaev VV, Shtro AA, Slita AV, Dukov MI, Shurygina AP, Smirnova TD, Kudryavtsev IV, Vasin AV, Kiselev OI. | Antiviral Res. 2015 Jan;113:4-10. | DOI:10.1016/j.antiviral.2014.10.015 | PMID:25446335 PMID25446335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25446335/
RECORD: Rec_0138028 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperSynthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments. Antiviral Res. 2015 Jan;113:4-10. doi: 10.1016/j.antiviral.2014.10.015. PMID: 25446335. PMID25446335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25446335/
RECORD: Rec_0253034 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Influenza A virus(A/California/07/2009 (H1N1)pdm09/):antiviral activity of the peptide in MDCK cells
23±1 μM
ED50
PaperSynthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments. Antiviral Res. 2015 Jan;113:4-10. doi: 10.1016/j.antiviral.2014.10.015. PMID: 25446335. PMID25446335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25446335/