Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2335H3726N606O671S19

DescriptionStandard

        MVWIVTVVLLFLSSHTICTNPALKARVTQQALDYGRQVGMQVLQEELKKINIPDVSGSTHVSVIGKVHYQISGIRIQAFSIAQSTVAFSPGTGMKLSLDNTNIAIHGNWRVKYSLGRDSGSFDVSVNGFSVSALIGMSTDQTGRPAVKSMGCSSNVGSLRLKLHGGASWLYNLFRSSLEKPIHSALVREICPKVSEAINSLELKLQRLKVTANVDKIAEIDYFLVNPPVITETFMDLDFKGEFYNIGRHQEPPFTAGPLSFPEQTNHMMYLAVSEFFFNSAAFVYHRAGALQINITDSMIPKSSPIRLNTSTFGGFIPQLKKLYPEMLMLMKIHSLKQPALTMTSDNITIAMTGAADTFAILPNSSLAPLFVLNLDVSVSATPSLSGDKLTGSLVINRLGLSLEHSDIGPFETSTLQGMLNVVTKIIVLPKINAFLAKGYPLPSVDQLSFVNPTIKVKEKFLMIATDIKYTL
    

Molecular Weight51633.45 Da

Isoelectric Point (pI)9.11

Net Charge (pH 7.0)7.46

Net Charge (pH 7.4) 6.54

Charge Density (pH 7.0) 0.0158

GRAVY Index0.17

Hydrophobic Moment 0.68

Boman Index0.16

Instability Index31.46

Aliphatic Index 102.01

Aromaticity 0.0805

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33015.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0264481 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinchus milii [Animal]

FamilyBPI

Tax ID7868

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence