Peptide Database

Peptide NameHepcidin (fish, chordates, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC98H165N39O22S9

DescriptionStandard

        RCRFCCRCCPRMRGCGICCRF
    

Molecular Weight2530.19 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)5.68

Net Charge (pH 7.4) 5.36

Charge Density (pH 7.0) 0.2705

GRAVY Index0.12

Hydrophobic Moment 0.65

Boman Index-0.35

Instability Index3.43

Aliphatic Index 18.57

Aromaticity 0.0952

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1007.93

LogP -11.83

H-bond Donors 47.0

H-bond Acceptors 37.0

Rotatable Bonds 81.0

Heavy Atoms 168.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0399515 VERIFIED: YES

Provenance & Taxonomy

OrganismLarimichthys crocea [Animal]

FamilyHepcidin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide2-19, 5-8, 6-15, 9-18

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetglutamicum

Activity3 μM

MethodMIC

RECORD: Rec_0404456 VERIFIED: YES

Provenance & Taxonomy

OrganismLarimichthys crocea [Animal]

FamilyHepcidin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide2-19, 5-8, 6-15, 9-18

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetBacillus subtilis

Activity6 μM

MethodMIC

RECORD: Rec_0407201 VERIFIED: YES

Provenance & Taxonomy

OrganismLarimichthys crocea [Animal]

FamilyHepcidin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide2-19, 5-8, 6-15, 9-18

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetepidermis

Activity12 μM

MethodMIC

RECORD: Rec_0415531 VERIFIED: YES

Provenance & Taxonomy

OrganismLarimichthys crocea [Animal]

FamilyHepcidin

Tax ID215358

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-19; 5-8; 6-15; 9-18

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Antibacterial Antifungal Hormone Endocrine Immunomodulatory ACE inhibitory

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min

RECORD: Rec_0421351 VERIFIED: YES

Provenance & Taxonomy

OrganismLarimichthys crocea [Animal]

FamilyHepcidin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide2-19, 5-8, 6-15, 9-18

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetlysodeikticus

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