Peptide Database

Peptide Namenatriuretic peptide PaNP-c

Function Ontology

Antimicrobial

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC161H260N50O55S3

DescriptionStandard

        SGSKTAEIGDGCFGVPIDHIGSTSGMGCGRPRPKPTPGGS
    

Molecular Weight3872.28 Da

Isoelectric Point (pI)7.81

Net Charge (pH 7.0)0.53

Net Charge (pH 7.4) 0.24

Charge Density (pH 7.0) 0.0133

GRAVY Index-0.48

Hydrophobic Moment 0.34

Boman Index0.04

Instability Index39.31

Aliphatic Index 39.00

Aromaticity 0.0250

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1632.53

LogP -25.51

H-bond Donors 58.0

H-bond Acceptors 60.0

Rotatable Bonds 121.0

Heavy Atoms 269.0

Ring Count 7.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0010467 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudechis australis [Animal]

Familynatriuretic peptide PaNP

Tax ID8670

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0184099 VERIFIED: NO

Provenance & Taxonomy

OrganismPseudonaja textilis [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0363944 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudechis australis [Animal]

Familynatriuretic peptide PaNP

Tax ID8670

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Targetconverting enzyme

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour