Peptide Database

Peptide NameNatriuretic peptide PtNP-a

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC151H253N51O49S3

DescriptionStandard

        SGSKIGNGCFGLPLDRISNTSGMGCRNPIQNRPKS
    

Molecular Weight3663.13 Da

Isoelectric Point (pI)10.10

Net Charge (pH 7.0)3.44

Net Charge (pH 7.4) 3.20

Charge Density (pH 7.0) 0.0983

GRAVY Index-0.67

Hydrophobic Moment 0.48

Boman Index-0.13

Instability Index9.70

Aliphatic Index 55.71

Aromaticity 0.0286

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1638.22

LogP -25.09

H-bond Donors 58.0

H-bond Acceptors 56.0

Rotatable Bonds 122.0

Heavy Atoms 254.0

Ring Count 4.0

Amide Bonds 39.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0063032 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudonaja textilis [Animal]

FamilyNatriuretic peptide PtNP

Tax ID8673

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-25

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0307388 VERIFIED: YES