Peptide Database

Peptide NameE1P38-1

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC105H149N25O27S2

DescriptionStandard

        LTCAVACELKWESEFWRW
    

Molecular Weight2257.59 Da

Isoelectric Point (pI)4.79

Net Charge (pH 7.0)-1.25

Net Charge (pH 7.4) -1.49

Charge Density (pH 7.0) -0.0696

GRAVY Index0.01

Hydrophobic Moment 0.44

Boman Index0.12

Instability Index82.36

Aliphatic Index 70.56

Aromaticity 0.2222

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 845.67

LogP -2.94

H-bond Donors 33.0

H-bond Acceptors 28.0

Rotatable Bonds 69.0

Heavy Atoms 159.0

Ring Count 7.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0104395 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetVirus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells

Activity125 μM

MethodIC50

RECORD: Rec_0209227 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAurein

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 NL4-3

Activity125 μM

MethodIC50

RECORD: Rec_0219740 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity125 μM

MethodIC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperDefinition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor. | Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I. | Biochim Biophys Acta. 2016 Jun;1860(6):1139-48. | DOI:10.1016/j.bbagen.2016.02.008 | PMID:26905802 PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/