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MYP_025586
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Basic Information
HYL
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
16 amino acids
C75H135N21O19S2
Standard
Sequence
GIMSSLMKKLAAHIAK
Physicochemical Analysis
1699.13 Da
10.30
2.84
2.59
0.1778
0.56
0.54
0.20
60.42
116.25
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
647.02
-4.61
23.0
25.0
61.0
117.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0303624 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(11) and Ⓧ (15) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
CCD-19Lu
4.76±0.03 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0304036 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(11) and Ⓧ (15) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
Endometrial epithelial cells (HEEC)
2.66±0.34 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0305367 VERIFIED: YES
Provenance & Taxonomy
Solitary wild [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
18 μM
MIC
PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/
RECORD: Rec_0319957 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(11) and Ⓧ (15) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
Normal Human Hepatic Cell (Lo-2)
2.91±0.07 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0342148 VERIFIED: YES
Provenance & Taxonomy
Solitary wild [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus epidermidis
13 μM
MIC
PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/
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