Peptide Database

Peptide NameHYL

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity

Venom / Toxin ▸ General toxin ▸ Cytotoxicity

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC75H135N21O19S2

DescriptionStandard

        GIMSSLMKKLAAHIAK
    

Molecular Weight1699.13 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)2.84

Net Charge (pH 7.4) 2.59

Charge Density (pH 7.0) 0.1778

GRAVY Index0.56

Hydrophobic Moment 0.54

Boman Index0.20

Instability Index60.42

Aliphatic Index 116.25

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 647.02

LogP -4.61

H-bond Donors 23.0

H-bond Acceptors 25.0

Rotatable Bonds 61.0

Heavy Atoms 117.0

Ring Count 1.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0262831 VERIFIED: YES

Provenance & Taxonomy

OrganismHylaeus signatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetEscherichia coli

Activity15 μM

MethodMIC

RECORD: Rec_0268721 VERIFIED: YES

Provenance & Taxonomy

OrganismHylaeus signatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetCandida albicans

Activity18 μM

MethodMIC

RECORD: Rec_0286333 VERIFIED: YES

Provenance & Taxonomy

OrganismSolitary wild [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/

RECORD: Rec_0288275 VERIFIED: YES

Provenance & Taxonomy

OrganismHylaeus signatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans

Activity18 μM

MethodMIC

RECORD: Rec_0294454 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHYL

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsStapled: Ⓧ(11) and Ⓧ (15) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Cytotoxicity

TargetHuman Splenic Fibroblasts (HSF)

Activity12.78±0.33 μg/mL

MethodIC50

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