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MYP_025586
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Basic Information
HYL
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
16 amino acids
C75H135N21O19S2
Standard
Sequence
GIMSSLMKKLAAHIAK
Physicochemical Analysis
1699.13 Da
10.30
2.84
2.59
0.1778
0.56
0.54
0.20
60.42
116.25
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
647.02
-4.61
23.0
25.0
61.0
117.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001302 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylaeus signatus [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
several strains of pathogenic bacteria Staphylococcus aureus
53-63 μM
MIC
PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics
RECORD: Rec_0001859 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylaeus signatus [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa 5482
20-68 μM
MIC
PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics
RECORD: Rec_0005221 VERIFIED: YES
Provenance & Taxonomy
Hylaeus signatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Human RBCs
400 μM
LC50
PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/
RECORD: Rec_0051571 VERIFIED: YES
Provenance & Taxonomy
Solitary wild [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/
RECORD: Rec_0056043 VERIFIED: YES
Provenance & Taxonomy
Solitary wild [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus 6271
63 μM
MIC
PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/
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