Peptide Database

Peptide NameCholecystokinin-70

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC335H542N104O99S3

DescriptionStandard

        APSSAGPLKPVPRLDGSIDQRANIGALLAKYLQQARKGPTGRISVMGNRVQSIDPTHRINDRDYMGWMDF
    

Molecular Weight7706.72 Da

Isoelectric Point (pI)10.14

Net Charge (pH 7.0)3.88

Net Charge (pH 7.4) 3.63

Charge Density (pH 7.0) 0.0555

GRAVY Index-0.57

Hydrophobic Moment 0.57

Boman Index-0.10

Instability Index44.63

Aliphatic Index 76.71

Aromaticity 0.0571

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3281.81

LogP -36.57

H-bond Donors 113.0

H-bond Acceptors 107.0

Rotatable Bonds 252.0

Heavy Atoms 541.0

Ring Count 12.0

Amide Bonds 76.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0100814 VERIFIED: YES

Provenance & Taxonomy

OrganismStruthio camelus [Animal]

FamilyCholecystokinin

Tax ID8801

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods64:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0145466 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0158944 VERIFIED: NO

Provenance & Taxonomy

OrganismStruthio camelus [Animal]

FamilyGastrin/cholecystokinin

Tax ID8801

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsTyr64 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide