Peptide Database

Peptide NameSLAY-screened peptide P4004

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H163N29O32S

DescriptionStandard

        WLWDRTLSTPLLVNSQCHDY
    

Molecular Weight2447.72 Da

Isoelectric Point (pI)5.21

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.43

Charge Density (pH 7.0) -0.0581

GRAVY Index-0.38

Hydrophobic Moment 0.34

Boman Index0.04

Instability Index45.90

Aliphatic Index 92.50

Aromaticity 0.1500

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 991.52

LogP -7.65

H-bond Donors 36.0

H-bond Acceptors 33.0

Rotatable Bonds 73.0

Heavy Atoms 173.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0136594 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/