Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length62 amino acids

Chemical FormulaC276H446N82O95S8

DescriptionStandard

        MPKYDDFDLNLKQNISNSNNKEPRITSIKWCTPGTCNNTCQGNSTLKSNCCGGSLICSLGGC
    

Molecular Weight6689.51 Da

Isoelectric Point (pI)8.20

Net Charge (pH 7.0)1.43

Net Charge (pH 7.4) 1.10

Charge Density (pH 7.0) 0.0231

GRAVY Index-0.58

Hydrophobic Moment 0.46

Boman Index-0.08

Instability Index37.47

Aliphatic Index 56.61

Aromaticity 0.0484

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2906.02

LogP -42.67

H-bond Donors 104.0

H-bond Acceptors 105.0

Rotatable Bonds 223.0

Heavy Atoms 461.0

Ring Count 7.0

Amide Bonds 72.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420887 VERIFIED: NO

Provenance & Taxonomy

OrganismVagococcus fessus [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence