Peptide Database

Peptide NameAntimicrobial peptide defensin 3 (AgDef3)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length67 amino acids

Chemical FormulaC300H486N82O89S9

DescriptionStandard

        MKFAVVSFLLVALLGLVAVGEAQLKNLACVTNEGPKWANTYCAAVCHMSGRGAGSCNAKDECVCSMT
    

Molecular Weight6954.15 Da

Isoelectric Point (pI)7.58

Net Charge (pH 7.0)0.53

Net Charge (pH 7.4) 0.17

Charge Density (pH 7.0) 0.0080

GRAVY Index0.57

Hydrophobic Moment 0.46

Boman Index0.23

Instability Index23.36

Aliphatic Index 90.30

Aromaticity 0.0597

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2712.07

LogP -28.85

H-bond Donors 99.0

H-bond Acceptors 100.0

Rotatable Bonds 228.0

Heavy Atoms 480.0

Ring Count 7.0

Amide Bonds 71.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0269396 VERIFIED: YES

Provenance & Taxonomy

OrganismAnopheles gambiae [Animal]

FamilyDefensin

Tax ID7165

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria