Peptide Database

Peptide NameSLAY-screened peptide P4256

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC113H166N26O30S2

DescriptionStandard

        CNMLLPYLLNGQIYLSYNYH
    

Molecular Weight2432.81 Da

Isoelectric Point (pI)6.73

Net Charge (pH 7.0)-0.17

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0083

GRAVY Index0.14

Hydrophobic Moment 0.29

Boman Index0.27

Instability Index17.79

Aliphatic Index 117.00

Aromaticity 0.2000

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 909.62

LogP -4.65

H-bond Donors 31.0

H-bond Acceptors 33.0

Rotatable Bonds 74.0

Heavy Atoms 171.0

Ring Count 6.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0238046 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/