Peptide Database

Peptide NameLixisenatide

Function Ontology

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Standard StatusStandard

Sequence Length44 amino acids

Chemical FormulaC215H346N60O66S

DescriptionStandard

        HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK
    

Molecular Weight4859.48 Da

Isoelectric Point (pI)9.52

Net Charge (pH 7.0)2.85

Net Charge (pH 7.4) 2.58

Charge Density (pH 7.0) 0.0649

GRAVY Index-1.11

Hydrophobic Moment 0.71

Boman Index-0.20

Instability Index53.56

Aliphatic Index 46.59

Aromaticity 0.0682

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2054.37

LogP -22.31

H-bond Donors 70.0

H-bond Acceptors 71.0

Rotatable Bonds 169.0

Heavy Atoms 342.0

Ring Count 8.0

Amide Bonds 45.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0254885 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

Bio-Activity Profile

Function

-

RECORD: Rec_0355741 VERIFIED: YES

Provenance & Taxonomy

OrganismHeloderma suspectum [Animal]; synthetic construct [Synthetic]

FamilyGLP-1

Tax ID8554;32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antidiabetic GLP-1 receptor agonist

TargetHuman GLP-1 receptor

Half-LifeClinical/Human: 3 h