Peptide Database

Peptide NameUrotensin II

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC62H85N15O18S2

DescriptionStandard

        GGNSECFWKYCV
    

Molecular Weight1392.56 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-0.26

Net Charge (pH 7.4) -0.50

Charge Density (pH 7.0) -0.0216

GRAVY Index-0.23

Hydrophobic Moment 0.22

Boman Index0.14

Instability Index58.76

Aliphatic Index 24.17

Aromaticity 0.2500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 546.08

LogP -4.71

H-bond Donors 21.0

H-bond Acceptors 20.0

Rotatable Bonds 42.0

Heavy Atoms 97.0

Ring Count 4.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0157715 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]; Salmo gairdneri irideus [Animal]

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-11

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0432836 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyUrotensin II

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-11

Bio-Activity Profile

Function

Neuropeptide Cardiovascular Vasoconstrictor Smooth-muscle contraction

TargetOncorhynchus mykiss efferent branchial artery vascular rings

Activity8.30 pD2 (-log M)

MethodConcentration-response vascular-ring contraction assay

RECORD: Rec_0432837 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyUrotensin II

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-11

Bio-Activity Profile

Function

Neuropeptide Cardiovascular Vasoconstrictor Smooth-muscle contraction

TargetOncorhynchus mykiss celiacomesenteric artery vascular rings

Activity8.22 pD2 (-log M)

MethodConcentration-response vascular-ring contraction assay

RECORD: Rec_0432838 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyUrotensin II

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-11

Bio-Activity Profile

Function

Neuropeptide Cardiovascular Hypertensive

Targetconscious Oncorhynchus mykiss arterial blood pressure

Activity8 % increase

MethodIntracerebroventricular administration (500 pmol); arterial blood-pressure measurement