Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length481 amino acids

Chemical FormulaC2353H3685N599O685S27

DescriptionStandard

        MLPCVIVVFVLLSCACGENPAVQVILTNKGLQYGKHEGTGWIQEKLEQITFPDISGSVDIHIGRVYYTLSGVTIKKCDLPEPSVEFVQQSGLTTSIAGLSFALAGEWRNQFGVIHDGGSFDMAIFNIDVTSAVKLGSNAGGRLSVTSVNCKASVGDVSMQFHGGASWIFQPFVKYFKGHIIGIIQSKICPEVEDTIMNLDHHLQAMNVSFDVNKVLSFDVPLTGDPDIEPSNMKLGFKGEFHSIKTHAEPPFVAQEFVLPELAGYMLSVGLSEFTLNSASFGYFSAGQLQAFINDSMIPPYIPFRLNTSAMGGFIPQLPKMYPGLLMNLQVNARDAPMFSFQPGSGVLDVHICVKASATESNGTQVPLFTLYIDSRFTGKMMIADGKLKGSMMLNNVTLTLGSSEIGDFKTDALENGIKSGMVVVLGKLNAKLGEGIMLPRMKHAQLVNTVLKMQKGFVGIYSDVQILQTDRSSYLSTSYL
    

Molecular Weight52190.78 Da

Isoelectric Point (pI)5.89

Net Charge (pH 7.0)-6.57

Net Charge (pH 7.4) -7.55

Charge Density (pH 7.0) -0.0137

GRAVY Index0.17

Hydrophobic Moment 0.62

Boman Index0.19

Instability Index32.76

Aliphatic Index 93.58

Aromaticity 0.0915

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34755.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0409468 VERIFIED: NO

Provenance & Taxonomy

OrganismPoecilia formosa [Animal]

FamilyBPI/LBP

Tax ID48698

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria