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MYP_025168
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Basic Information
Thrombostatin con-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
19 amino acids
C87H142N34O29S2
Standard
Sequence
QPWSQCSATCGDGVRERRR
Physicochemical Analysis
2192.40 Da
9.02
1.74
1.51
0.0918
-1.40
0.40
-0.51
84.56
20.53
0.0526
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1063.19
-15.56
41.0
33.0
71.0
152.0
3.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0292537 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Thrombostatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic
Endothelial screening context
PaperSupporting Information for Karagiannis and Popel, PNAS (10.1073/pnas.0803241105) PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0296024 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0337425 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
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