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MYP_025163
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Basic Information
Antifungal cyclic dipeptide
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0138216 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Benzyloxycarbonyl
Aldehyde
HPhe- homophenylalanine
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum W2
0.02 μM
IC50; Flourimetry (Hydrolysis of the fluorogenic substrate)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
RECORD: Rec_0168812 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
X=Hyp
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID27806640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27806640/
RECORD: Rec_0169563 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Fluoromethyl ketone
Homophenylalanine (HPhe)
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Itg2
0.003 μM
IC50; Microscopy (Giemsa staining)
PMID8450035 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8450035/
RECORD: Rec_0263759 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Vinyl sulfone
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium vinckei
0.1 μM
IC50; Fluorimetry (fluorescence by hydrolysis of benzyloxycarbonyl-Phe-Arg-7-amino-4-methyl-coumarin measured)
PaperAntimalarial effects of vinyl sulfone cysteine proteinase inhibitors PMID8807047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8807047/
RECORD: Rec_0266439 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Phenylsulfonyl
Aldehyde
HPhe- homophenylalanine
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum W2
0.031 μM
IC50; Flourimetry (Hydrolysis of the fluorogenic substrate)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
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