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MYP_025163
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Basic Information
Antifungal cyclic dipeptide
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076887 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Vinyl sulfone
Ser(OBzl)=benzyl group bound to the serine side chain hydroxyl group
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium vinckei
0.5 μM
IC50; Fluorimetry (fluorescence by hydrolysis of benzyloxycarbonyl-Phe-Arg-7-amino-4-methyl-coumarin measured)
PaperAntimalarial effects of vinyl sulfone cysteine proteinase inhibitors PMID8807047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8807047/
RECORD: Rec_0089494 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Vinyl sulfone
Ser(OBzl)=benzyl group bound to the serine side chain hydroxyl group
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Itg2
1 μM
IC50; Fluorimetry (fluorescence by hydrolysis of benzyloxycarbonyl-Phe-Arg-7-amino-4-methyl-coumarin measured)
PaperAntimalarial effects of vinyl sulfone cysteine proteinase inhibitors PMID8807047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8807047/
RECORD: Rec_0096614 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
Z=Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Antiparasitic Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0114784 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
diketopiperazine
32630
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
Ornithine (Z)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anticancer Antimalarial Antiparasitic
Plasmodium berghei ANKA 2.34
123.02 μM
IC50; Microscopy
PMID23084276 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23084276/
RECORD: Rec_0125715 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Vinyl sulfone
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Itg2
0.08 μM
IC50; Fluorimetry (fluorescence by hydrolysis of benzyloxycarbonyl-Phe-Arg-7-amino-4-methyl-coumarin measured)
PaperAntimalarial effects of vinyl sulfone cysteine proteinase inhibitors PMID8807047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8807047/
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