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MYP_025163
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Basic Information
Antifungal cyclic dipeptide
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FX
Physicochemical Analysis
0.00 Da
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0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000754 VERIFIED: NO
Provenance & Taxonomy
Lactobacillus plantarum [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
cyclic peptide, P2: trans-4-OH-L-proline
Bio-Activity Profile
Antimicrobial Antifungal
Aspergillus fumigatus and, Penicillium roqueforti
RECORD: Rec_0006326 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
Mu=morpholine urea
VS=vinyl-sulfone,Me=methyl
Homophenylalanine (HPhe)
Bio-Activity Profile
Antimicrobial Antiparasitic Antiplasmodial Cysteine protease inhibitor
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0013723 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Mu=Morpholine urea
CH2F
HPhe=Homophenylalanine
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial Cysteine protease inhibitor
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0020239 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
OMe
None
X=Sar
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID23084276 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23084276/
RECORD: Rec_0021627 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Aldehyde
HPhe- homophenylalanine
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum W2
0.01 μM
IC50; Microscopy (Giemsa staining)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
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