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MYP_025123
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Basic Information
Smp76
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
76 amino acids
C362H595N105O106S9
Standard
Sequence
GWINEKKMQQKIDEKIGKNIIGGMAKAVIHKMAKNEFQCVANVDTLGNCKKHCAKTTGEKGYCHGTKCKCGIELSY
Physicochemical Analysis
8402.82 Da
9.22
6.96
6.49
0.0916
-0.57
0.63
-0.08
28.35
64.21
0.0526
8480.00
8855.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3459.36
-35.71
123.0
125.0
300.0
582.0
8.0
83.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0135536 VERIFIED: YES
Provenance & Taxonomy
Scorpio maurus palmatu [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
PaperThe Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-I Interferon Response
RECORD: Rec_0149260 VERIFIED: YES
Provenance & Taxonomy
Scorpio maurus [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
39-63, 49-68, 53-70
Bio-Activity Profile
Antimicrobial Antiviral
Dengue Virus(DENV):inhibition of viral infection in Vero/SLAM cells
0.01 μg/mL
IC50
PaperPubMed PMID: 32435168 PMID32435168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32435168/
RECORD: Rec_0207095 VERIFIED: YES
Provenance & Taxonomy
Scorpio maurus [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
39-63, 49-68, 53-70
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 32435168 PMID32435168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32435168/
RECORD: Rec_0212675 VERIFIED: YES
Provenance & Taxonomy
Scorpio maurus [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
39-63, 49-68, 53-70
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
PaperPubMed PMID: 32435168 PMID32435168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32435168/
RECORD: Rec_0257109 VERIFIED: YES
Provenance & Taxonomy
Scorpio palmatus [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
39-63, 49-68, 53-70
Disulfide bonds between Cys39 and Cys63, Cys49 and Cys68, Cys53 and Cys70.
Bio-Activity Profile
Antiviral Anti-DENV Infection inhibition
Dengue Virus(DENV) | Vero/SLAM cells
0.00119 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperSmp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus. | El-Bitar AMH, Sarhan M, Abdel-Rahman MA, Quintero-Hernandez V, Aoki-Utsubo C, Moustafa MA, Possani LD, Hotta H. | Int J Pept Res Ther. 2020;26(2):811-821. | DOI:10.1007/s10989-019-09888-2 | PMID:32435168 PMID32435168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32435168/
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