Peptide Database

Peptide NamePexelizumab

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length250 amino acids

Chemical FormulaC1175H1792N312O376S9

DescriptionStandard

        MADIQMTQSPSSLSASVGDRVTITCGASENIYGALNWYQRKPGKAPKLLIYGATNLADGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQNVLNTPLTFGQGTKVEIKRTGGGGSGGGGSGGGGSQVQLVQSGAEVEKPGASVKKVSCKASGYIFSNYWIQWVRQAPGQGLEWMGEILPGSGSTEYAQKFQGRVTMTADTSTSTAYMELSSLRSEDTAVYYCARYFFGSSPNYWYFDVWGQGTLVTVSS
    

Molecular Weight26593.25 Da

Isoelectric Point (pI)6.31

Net Charge (pH 7.0)-0.53

Net Charge (pH 7.4) -0.86

Charge Density (pH 7.0) -0.0021

GRAVY Index-0.29

Hydrophobic Moment 0.59

Boman Index0.09

Instability Index37.57

Aliphatic Index 62.80

Aromaticity 0.1160

Extinction Coeff. Reduced 55350.00

Extinction Coeff. Oxidized 55600.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0212384 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMonoclonal antibody

Tax ID32630

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Complement C5 inhibitor Immunomodulatory

Targethuman complement component C5

Methodcomplement-dependent serum hemolytic activity assay

Half-Life7.0 hours to 14.5 hours.