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MYP_025096
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Basic Information
Pyrularia thionin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
47 amino acids
C220H362N68O67S8
Standard
Sequence
KSCCRNTWARNCYNVCRLPGTISREICAKKCDCKIISGTTCPSDYPK
Physicochemical Analysis
5288.16 Da
9.06
5.68
5.35
0.1208
-0.51
0.70
-0.20
34.95
51.91
0.0638
8480.00
8980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2212.51
-27.90
87.0
81.0
172.0
363.0
7.0
49.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044626 VERIFIED: NO
Provenance & Taxonomy
Insecta [Animal]
50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0147525 VERIFIED: YES
Provenance & Taxonomy
Pyrularia pubera [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
PaperA toxic thionin from Pyrularia pubera: purification, properties, and amino acid sequence.
RECORD: Rec_0165591 VERIFIED: YES
Provenance & Taxonomy
Pyrularia pubera [Plant]
Thionin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
disulfide-stabilized; exact pairings not extracted
Bio-Activity Profile
Anticancer Antimicrobial
B16 melanoma cells
40 μg/mL
PaperA toxic thionin from Pyrularia pubera: purification, properties, and amino acid sequence PMID3985614 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3985614/
RECORD: Rec_0187071 VERIFIED: YES
Provenance & Taxonomy
Pyrularia pubera [Plant]
Thionin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Xanthomonas campestris
3.67±0.58 μM
IC50
PaperPubMed PMID 15494403 | PubMed PMID 3985614 PMID15494403;3985614 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15494403/
RECORD: Rec_0211989 VERIFIED: YES
Provenance & Taxonomy
Pyrularia pubera [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Cytotoxic
PaperPubMed PMID: 3985614 PMID3985614 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3985614/
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