Peptide Database

Peptide NameSLAY-screened peptide P5137

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC111H166N34O35S2

DescriptionStandard

        TFKAEMILRHCYDYDNRHSSN
    

Molecular Weight2600.84 Da

Isoelectric Point (pI)6.61

Net Charge (pH 7.0)-0.44

Net Charge (pH 7.4) -0.75

Charge Density (pH 7.0) -0.0207

GRAVY Index-1.16

Hydrophobic Moment 0.59

Boman Index-0.29

Instability Index76.65

Aliphatic Index 41.90

Aromaticity 0.1429

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1151.73

LogP -12.45

H-bond Donors 42.0

H-bond Acceptors 39.0

Rotatable Bonds 85.0

Heavy Atoms 182.0

Ring Count 5.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0301263 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/