Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length455 amino acids

Chemical FormulaC2300H3573N573O672S12

DescriptionStandard

        MLKEKNLPDLSGSESLEFLKVDYVNYNFSNIKIKAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLRLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLADPPFSPVPVVLPERSNSMLYIGIAEYFFKSASFAYFTAGAFNVTLSTKEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPVINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHGWEGLNLISGQWRGKSAP
    

Molecular Weight50388.19 Da

Isoelectric Point (pI)5.19

Net Charge (pH 7.0)-11.77

Net Charge (pH 7.4) -12.54

Charge Density (pH 7.0) -0.0259

GRAVY Index0.12

Hydrophobic Moment 0.63

Boman Index0.17

Instability Index38.99

Aliphatic Index 101.98

Aromaticity 0.1033

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207853 VERIFIED: NO

Provenance & Taxonomy

OrganismColobus angolensis palliatus [Animal]

FamilyBPI

Tax ID336983

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence